Wednesday, March 19, 2014

Your Plastic Brain 5—The Future?


“Hey, Curmudge, I though we had wrapped up our brain plasticity discussions several weeks ago.  But then we had Even More Applications, and here we are back at it again to look into the future.”

“Sorry, Julie.  My self-control must have gone kaput.  I couldn’t resist looking into the on-going and near-future research at places like the Stanford Institute for Neuro-Innovation & Translational Neurosciences (SINTN).  SINTN is divided into five interrelated, interdisciplinary initiatives.  To provide a flavor of their work, I’ll quote a sentence about some of the initiatives from their website.

Neuroengineering: ‘Scientists are learning how to use technology to restore brain circuit abnormalities resulting from stroke, degenerative disease, or even depression.’

 Neurodegeneration and Regeneration: ‘Many terrible diseases of the nervous system involve massive neuron loss. Researchers are discovering that there are a lot of similarities in the way that those neurons are lost in disorders as disparate as Parkinson’s, Alzheimer’s, Huntington’s, and Lou Gehrig’s diseases, blindness by macular degeneration, and even spinal cord injury.’

Neurobiology of Cognitive and Developmental Defects: ‘The development of the brain is one of nature’s most remarkable accomplishments, involving a complex orchestration of genetic mechanisms and environmental influences during infancy and childhood. When neurodevelopment goes wrong, cognitive disorders result, ranging from problems in learning and memory to difficulties recognizing normal social cues. The most common of these disorders are the autism spectrum disorders.’

Neural Plasticity and Repair: ‘Parkinson’s disease research is pushing forward on many fronts. Engineering and computational neuroscience are dovetailing with traditional and innovative models of the disease process in Parkinson’s. Treatments on the horizon include electrical and optical stimulation, gene therapy, and stem cell transplantation.’

Neuroscience and Society: ‘As part of its pursuit of advanced neuroscience research, SINTN scientists study neuroscience in a broader social context. Such research has the power to help us understand and harness positive qualities like the power of compassion and altruism, at the same time as we avoid negative implications of our growing neuroscientific understanding.’ “

“Gosh, Professor, one would expect that in a hot, relatively new area like neuroscience there would be research underway at universities in the East.”

“And there is, Julie, at the McGovern Institute for Brain Research at MIT.  Their research is organized around three broad themes: Perception, Cognition, and Action with several faculty members in each area.  Furthermore, to illustrate the interest in brain studies even to undergraduates, the faculty of Lawrence University here in Appleton recently approved creating a major and minor in neuroscience.”

“Wow, Curmudge, those are all impressive and ambitious undertakings.  And speaking of neuroscience and society, here’s a story that one of our editors told us about.  It’s based on a 2013 TED talk by Daniel Reisel.  MRI scans of psychopathic murderers had a deficient amygdala, which likely led to their lack of empathy and their immoral behavior.  Reisel’s subsequent work with mice revealed that those kept in a shoebox lost their ability to bond with other mice.  However, mice kept in an enriched environment showed growth of new brain cells and connections and performed better on learning and memory tasks.  Perhaps for humans, according to Reisel, we should consider rehabilitation programs such as Restorative Justice instead of incarceration for perpetrators.”

“Julie, I remain totally impressed by the scope of fundamental and applied research underway on brain plasticity.  A lot of this won’t help those of my generation, but it should really pay off for our grandchildren.”

“Old Guy, I must congratulate you for tackling topics that were much less significant 60 years ago when you were a student.”

“To set the record straight, Dear Colleague, the congrats must go to the younger members of our editorial board.  Doc Mack ignited our thinking about alternative medicine, and Elizabeth put us on the path to neuroscience.  And don’t go away; in the near future we’ll talk about some of the more sinister applications of neuroplasticity.”

“Never fear, Quixote, Sancho Panza will be with you until the snow melts.”
     
Kaizen Curmudgeon

Link to posting from blog archives: Amazing Devices 4—ultrasound, electronic stethoscope 9/09/10 http://kaizencurmudgeon.blogspot.com/2010/09/amazing-devices-4.html

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